UW Drug Discovery and Development Fee-for-Service Capabilities

The Office of Corporate Relations is your front door access to drug development opportunities at the University of Wisconsin–Madison.  This development process is conducted within a world-renowned academic environment, bolstered by a rigorous scientific community. Join other Wisconsin and US clients who have found solutions for their contracted drug development at UW–Madison.

Explore our areas of expertise and contact OCR by phone: 1-877-OCR-WISC (1-877-627-9472) or email: inquiries@ocr.wisc.edu.

  • High Throughput Screening and Medicinal Chemistry »

    • HTS of small molecule libraries on cell-based or biochemical assays
    • Mechanism of action and profiling assays on client provided compounds
    • Medicinal and synthetic chemistry, scale-up synthesis, natural product purification
    • Analytical determination of chemical purity/identity
    • Molecular modeling and virtual screening
  • Flow Cytometry »

    • Single cell analysis
    • Single cell sorting: single cell deposition and bulk sorting of live cells
    • Comprehensive assay services: sample prep, data acquisition and analysis for immunophenotyping, cell cycle, DNA content, apoptosis, phagocytosis, calcium flux, cytokine and phosphoprotein detection, mitochondrial membrane potential, oxidative burst
  • Histology/Pathology »

    • Microtomy and cryo sectioning; HE and special stains
    • IHC protocol development and optimization
    • Expert “in house” pathology consultation
    • Histologic staining methods to histopathologic assays
    • DNA/RNA isolation, quantitative real time RT-PCR analysis
    • Standardized IHC/IF/ISH through automation
    • Multispectral imaging system NuanceTM (manual) and VectraTM (automated) imaging
  • Pharmacology »

    • Pharmacokinetics (PK) and tissue distribution
    • Maximum tolerated dose (MTD) and optimal route of administration
    • Efficacy in xenograft and transgenic models
    • GLP compliant analysis
    • HPLC, LC-MS, LC-MS/MS, genomic and immunoassay development and validation
  • Formulation and Characterization »

    • Drug, biologic and excipient physical/chemical characterization (pre-formulation)
    • Formulation
    • Analytical method development and validation
    • Stability testing
    • Structural elucidation
  • Biomanufacturing »

    • Chemistry, Manufacturing and Control (CMC) support for Investigational New Drug (IND) for biologics filings including Facility Master File (CBER/CDER)
    • Process development/qualification/validation
    • Assay qualification/validation
    • cGMP manufacturing of pre-clinical and clinical material
    • Quality control testing
  • Human Blood/Tissue Biobank »

    • Isolation of human blood RNA and DNA
    • RNA, DNA, and protein sample quality determination
    • Human tissue sectioning, frozen or paraffin-embedded
    • Cryostat, Microtome, Bioanalyzer available for rental use
    • Consultation for histologic services
  • Small Animal Imaging »

    • Noninvasive, high-resolution in-vivo and ex-vivo
    • microCT and micro MRI (anatomical and functional)
    • microPET and optical imaging (functional)
    • Intraoperative Real Time Near-Infrared optical imaging (functional)
    • Imaging of targeted, non-targeted, vascular, and activatable contrast agents