The following laboratory facilities at UW-Madison provide state-of-the-art instrumentation and expert scientific staffs and have prior experience completing projects for Wisconsin and US companies. Contact a single facility by clicking on the link to learn how they can help advance your drug discovery or development program.
UWCCC Small Molecule Screening and Synthesis Facility
- HTS of small molecule libraries on cell-based or biochemical assays
- Mechanism of action and profiling assays on client provided compounds
- Medicinal and synthetic chemistry, scale-up synthesis, natural product purification
- Analytical determination of chemical purity/identity via the Analytical Instrumentation Center
- Molecular modeling and virtual screening
- Single cell analysis
- Single cell sorting: single cell deposition and bulk sorting of live cells
- Comprehensive assay services: sample prep, data acquisition and analysis for immunophenotyping, cell cycle, DNA content, apoptosis, phagocytosis, calcium flux, cytokine and phosphoprotein detection, mitochondrial membrane potential, oxidative burst
UWCCC Experimental Pathology Shared Resource
- Tissue processing, embedding and preparation of histologic sections
- Standard and specialized histologic stains and enzyme-based histochemistry
- Expert pathology consultation
UWCCC Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics Laboratory
- Pharmacokinetics (PK) and tissue distribution
- Maximum tolerated dose (MTD) and optimal route of administration
- Efficacy in xenograft and transgenic models
- GLP compliant analysis (if needed)
- HPLC, LC-MS, LC-MS/MS, genomic and immunoassay development and validation
UW School of Pharmacy: Zeeh Pharmaceutical Experiment Station
- Drug, biologic and excipient physical/chemical characterization (pre-formulation)
- Formulation
- Analytical method development and validation
- Stability testing
- Structural elucidation: Analytical Instrumentation Center
- Chemistry, Manufacturing and Control (CMC) support for Investigational New Drug (IND) for biologics filings including Facility Master File (CBER/CDER)
- Process development/qualification/validation
- Assay qualification/validation
- cGMP manufacturing of pre-clinical and clinical material
- Quality control testing